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Iodination of Terminal Alkynes Using KI/CuSO4 – A Facile Method with Potential for Radio-iodination

Author:
Ferris, Trevor, Carroll, Laurence, Mease, Ronnie C., Spivey, Alan C, Aboagye, Eric O.
Source:
Tetrahedron letters 2019
ISSN:
0040-4039
Subject:
acetates, acetonitrile, alkynes, chemical structure, copper sulfate, iodination
Abstract:
Herein, we report an efficient new method for the iodination of terminal alkynes using stoichiometric KI and CuSO4 in a mix of acetonitrile and acetate buffer that holds promise for further development into a method for radio-iodination.
Agid:
6328783