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In Vitro Study on Effect of Germinated Wheat on Human Breast Cancer Cells
- Cho, Kyongshin, Lee, Chiwon W., Ohm, Jae-Bom
- Cereal chemistry 2016 v.93 no.6 pp. 647-649
- antineoplastic activity, apoptosis, breast neoplasms, breasts, cell culture, cell proliferation, flow cytometry, growth retardation, human cell lines, humans, in vitro studies, neoplasm cells, phytopharmaceuticals, seed germination, wheat, wheat flour
- This research investigated the possible anticancer effects of germinated wheat flour (GWF) on growth and apoptosis of human breast cancer cells. In a series of in vitro experiments, estrogen-receptor-positive (MCF-7) and -negative (MDA-MB-231) cells were cultured and treated with GWF that was obtained after a three-day germination. The GWF significantly reduced the growth of both of MCF-7 and MDA-MB-231 cells. In analysis with a flow cytometer, the GWF significantly up-regulated apoptosis of both cell lines. These results indicate that GWF induced apoptosis and inhibited growth of the human breast cell lines, thereby demonstrating its potential inhibition of breast cancer cell proliferation.