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Differential effects in male adult rats of lifelong coconut oil exposure versus during early-life only
- Quitete, Fernanda Torres, de Moura, Egberto Gaspar, Atella, Geórgia Correa, Lisboa, Patricia Cristina, de Oliveira, Elaine
- Journal of functional foods 2019 v.55 pp. 17-27
- adults, animal models, breast feeding, coconut oil, males, mothers, overeating, overweight, progeny, pups, rats, soybean oil, thyrotropin, undereating, visceral fat, weaning
- We investigated the effects of maternal coconut oil supplementation during breastfeeding on the endocrine-metabolic profiles of offspring and the impact of continued exposure throughout life. Rat mothers were separated into: soybean oil (SO); and coconut oil (CO) groups and received the oils through gavage (0.5 g/kg of BW) and had free access to standard chow. After weaning, half of the pups from CO group continued receiving coconut oil in chow (CO + C), while SO and the other half of CO group received standard chow. Offspring were killed at postnatal day 180. CO and CO + C offspring had higher body masses, but only CO had higher visceral fat and lower lean mass. CO group exhibited hyperphagia and hyperleptinemia while CO + C group exhibited hypophagia. CO group had higher T3 and TSH. Coconut oil led to long-term overweight, hyperphagia, hyperleptinemia and thyroid dysfunction, whereas the continuous exposure throughout life prevented most of these dysfunctions.