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Megastigmane derivatives from Corispermum mongolicum and their anti-inflammatory activities
- Zhou, Yi, Jin, Mei, Jin, Chunshi, Ye, Chao, Wang, Jiaming, Wang, Rongshen, Wei, Chengxi, Zhou, Wei, Li, Gao
- Phytochemistry letters 2019
- anti-inflammatory activity, chemical constituents of plants, ethanol, glucosides, interleukin-6, nitric oxide, nuclear magnetic resonance spectroscopy, secretion, tumor necrosis factor-alpha
- Phytochemical investigation of the ethanol extract of the whole plant of Corispermum mongolicum Iljin led to the isolation of a new megastigmane, (―)-(3R)-hydroxysulfonyloxy-β-ionone (1), a new megastigmane glucoside, (3S,6S,9R)-3,9,13-trihydroxymegastigman-4-ene-3-O-β-D-glucopyranoside (2), as well as four known compounds (3–6). The structures of these new compounds were elucidated mainly by using NMR, HR-ESI-MS, and modified Mosher’s method. The anti-inflammatory activities of the isolated megastigmane derivatives were evaluated by examining the secretion of inflammatory markers (NO, TNF-α, and IL-6) by LPS-stimulated RAW 264.7 cells. Compounds 1–2, 4 and 5 exhibited anti-inflammatory activities, and compound 2 was found to possess better inhibitory activity than the other compounds tested.