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Two azafluoranthene alkaloids and a phytoecdysone from the stems of Cyclea barbata

Author:
Wang, Xiao-Jing, Zhang, Qi, Peng, Yu-Ru, Li, Li, Qu, Jing, Liu, Yun-Bao, Xu, Song, Ma, Shuang-Gang, Li, Yong, Zou, Zhong-Mei, Wang, Ru-Bing, Yu, Shi-Shan
Source:
Journal of Asian natural products research 2019 v.21 no.3 pp. 217-226
ISSN:
1477-2213
Subject:
Cyclea barbata, acetaminophen, alkaloids, bioassays, hepatoprotective effect, human cell lines, spectral analysis, stems, toxicity
Abstract:
Two new azafluoranthene alkaloids (1 and 2), and a new phytoecdysone (3), were isolated from the stems of Cyclea barbata Miers, together with six known compounds (4–9). Their structures were elucidated by spectroscopic data analysis and comparison with published data. This is the first report of azafluoranthene alkaloids (1 and 2) and phytoecdysones (3, 8, and 9) from Cyclea genus. In in vitro bioassay, four isolates (3, 5, 6, and 9) showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells.
Agid:
6331883