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Integrated pH Measurement during Reaction Monitoring with Dual-Reception ¹H–³¹P NMR Spectroscopy

Author:
Cox, Neil, Kuemmerle, Rainer, Millard, Pierre, Cahoreau, Edern, François, Jean-Marie, Parrou, Jean-Luc, Lippens, Guy
Source:
Analytical chemistry 2019 v.91 no.6 pp. 3959-3963
ISSN:
1520-6882
Subject:
monitoring, nuclear magnetic resonance spectroscopy, pH, phosphates, phosphorus, stable isotopes
Abstract:
Simultaneous detection of ¹H and ³¹P NMR signals through a dual-detection scheme with two receivers allows monitoring of both the signals of a molecule and the pH of the solution through the resonance of the inorganic phosphate. We evaluate here the method in terms of sensitivity and ease of implementation and show that the additional information obtained without any loss of information or increase in measuring time can be of practical importance in a number of biochemical systems.
Agid:
6331929