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Red-emitting pyrene–benzothiazolium: unexpected selectivity to lysosomes for real-time cell imaging without alkalinizing effect

Author:
Abeywickrama, Chathura S., Wijesinghe, Kaveesha J., Stahelin, Robert V., Pang, Yi
Source:
Chemical communications 2019 v.55 no.24 pp. 3469-3472
ISSN:
1364-548X
Subject:
biocompatibility, chemical compounds, chemical reactions, image analysis, lysosomes
Abstract:
A series of pyrene–benzothiazolium probes were synthesized. By replacing the pyridinium with a benzothiazolium unit, the selectivity of pyrene-derivatives is found to switch from nuclear to cellular lysosomes. New probes do not require proton participation and exhibit high biocompatibility and long-term imaging ability.
Agid:
6332179