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A New Prenylated Coumarin from Daphne oleoides and its Cytotoxic Activity

Author:
Dar, Muhammad Younus, Ara, Tabassum, Akbar, Seema
Source:
Chemistry of natural compounds 2019 v.55 no.1 pp. 5-7
ISSN:
0009-3130
Subject:
Daphne oleoides, breast neoplasms, cell lines, chemistry, coumarin, cytotoxicity, ethyl acetate, humans, inhibitory concentration 50, lung neoplasms, spectral analysis, uterine cervical neoplasms
Abstract:
A new prenylated coumarin, 7-(4′-methylpentoxy)-2H-1-benzopyran-2-one (1), together with two known coumarins (2, 3), was isolated from the ethyl acetate extract of Daphne oleoides (Thymelaeaceae). Their structures were elucidated on the basis of extensive spectroscopic analysis. The three compounds (1–3) were screened for preliminary cytotoxic activity using MTT assay on human breast cancer (HBL-100), lung cancer (A549), and cervical cancer (HeLa) cell lines, which revealed that the compounds possess in vitro cytotoxic activity with IC₅₀ values ranging between 23.99–49.13 μg/mL.
Agid:
6332302