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A New Triterpenoid and Bioactive Constituents of Eriobotrya deflexa f. buisanensis

Author:
Chen, Jih-Jung, Wu, Ru-Fang, Hsiao, Jen-Wen, Chen, Li-Chai, Zhu, Tong-Fei, Kuo, Yueh-Hsiung, Sung, Ping-Jyun, Cheng, Ming-Jen, Chang, Tzu-Cheng
Source:
Chemistry of natural compounds 2019 v.55 no.1 pp. 74-78
ISSN:
0009-3130
Subject:
Dengue virus, Eriobotrya deflexa, chemistry, inhibitory concentration 50, leaves, nitric oxide, oleanolic acid, spectroscopy, viruses
Abstract:
A new triterpenoid, methyl 2α-O-trans-feruloyl-3β-hydroxy-urs-12-en-28-oate (1), has been isolated from the leaves of Eriobotrya deflexa f. buisanensis, together with five known compounds, methyl ursolate (2), oleanolic acid (3), corosolic acid (4), 3-O-trans-caffeoyltormentic acid (5), and tormentic acid (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, oleanolic acid (3), corosolic acid (4), and tormentic acid (6) showed potent inhibition with IC₅₀ values of 16.3 ± 1.8, 20.4 ± 2.2, and 18.3 ± 1.4 μM, respectively, against LPS-induced NO generation. In addition, 3-O-trans-caffeoyltormentic acid (5) exhibited anti-Dengue virus activity with IC₅₀ value of 12.4 ± 1.1 μM against Dengue virus serotype 2 strain PL046.
Agid:
6332311