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A New Lipoxygenase Inhibitory Flavonoid from the Kino of Eucalyptus citriodora

Author:
Lee, Shwu-Woan
Source:
Chemistry of natural compounds 2019 v.55 no.1 pp. 18-20
ISSN:
0009-3130
Subject:
Corymbia citriodora, caffeic acid, chemistry, cinnamic acid, enzyme inhibition, gallic acid, inhibitory concentration 50, lipoxygenase, nuclear magnetic resonance spectroscopy, p-coumaric acid, quercetin
Abstract:
A new lipoxygenase inhibitory flavonoid, 8-[1-(p-hydroxyphenyl)ethyl]rhamnocitrin (1), together with four known compounds, cinnamic acid (2), p-coumaric acid (3), caffeic acid (4), and gallic acid (5), was isolated from the kino of Eucalyptus citriodora, and their structures were elucidated on the basis of spectroscopic methods including 2D NMR spectra. These compounds were tested for inhibitory activity against 15-lipoxygenase. Compound 1 showed stronger inhibitory activity (IC₅₀ 27.6 ± 0.7 μM) than the positive control quercetin (IC₅₀ 37.5 ± 0.8 μM).
Agid:
6332317