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Self-Assembling Nanoparticles Usher in a New Era of Vaccine Design
- Rappuoli, Rino, Serruto, Davide
- Cell 2019 v.176 no.6 pp. 1245-1247
- Respiratory syncytial virus, adjuvants, antigens, nanoparticles, vaccines
- In this issue, Marcandalli et al. (2019) report a self-assembling nanoparticle bearing an antigen from respiratory syncytial virus. This is the first time the structure, stability, and adjuvanticity of an antigen have been rationally designed at the atomic level and incorporated in one vaccine.