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An Error-Prone Polymerase in the Fight against Cancer
- Achar, Yathish Jagadheesh, Foiani, Marco
- Cell 2019 v.176 no.6 pp. 1241-1243
- DNA, animal models, enzymes, in vitro studies, mutagens, risk, skin neoplasms
- Error-prone polymerases are alleged to induce mutations while replicating damaged DNA and to increase the risk of cancer. Using in vitro studies and mice models, Yoon et al. (2019) provide evidence that the error-prone Pol θ polymerase protects against ultraviolet light-induced skin cancer despite its mutagenic potential.