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RNA Splicing: A New Paradigm in Host–Pathogen Interactions

Chauhan, Komal, Kalam, Haroon, Dutt, Ravi, Kumar, Dhiraj
Journal of molecular biology 2019 v.431 no.8 pp. 1565-1575
alternative splicing, genes, host-pathogen relationships, immune response, microorganisms, neoplasms, pathogens, proteome, stoichiometry
RNA splicing brings diversity to the eukaryotic proteome. Different spliced variants of a gene may differ in their structure, function, localization, and stability influencing protein stoichiometry and physiological outcomes. Alternate spliced variants of different genes are known to associate with various chronic pathologies including cancer. Emerging evidence suggests precise regulation of splicing as fundamental to normal well-being. In this context, infection-induced alternative splicing has emerged as a new pivot of host function, which pathogenic microbes can alter—directly or indirectly—to tweak the host immune responses against the pathogen. The implications of these findings are vast, and although not explored much in the case of pathogenic infections, we present here examples from splicing mediated regulation of immune responses across a variety of conditions and explore how this fascinating finding brings a new paradigm to host–pathogen interactions.