PubAg

Main content area

Oxidative phenol-arene and phenol-phenol cross-coupling using periodic acid

Author:
Gao, Peng-Cheng, Chen, Huan, Grigoryants, Vladimir, Zhang, Qiang
Source:
Tetrahedron 2019 v.75 no.13 pp. 2004-2011
ISSN:
0040-4020
Subject:
ambient temperature, chemical structure, cross-coupling reactions, naphthols, phenol
Abstract:
A simple, metal-free protocol for unsymmetrical biaryl coupling using H5IO6 is reported. H5IO6 was evaluated for a novel application in the oxidative cross-coupling of phenol-arene, phenol-phenol, and phenol-naphthol compounds. In this work, most of the couplings were completed within 30 min at ambient temperature. 30 coupling products were conveniently obtained using only 0.5 equivalent of H5IO6 in HFIP. A mechanism by which the transformation occurs is proposed.
Agid:
6335325