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Activation of nitriles by silver(I) N-heterocyclic carbenes: An efficient on-water synthesis of primary amides

Author:
Thirukovela, Narasimha Swamy, Balaboina, Ramesh, Kankala, Shravankumar, Vadde, Ravindhar, Vasam, Chandra Sekhar
Source:
Tetrahedron 2019 v.75 no.18 pp. 2637-2641
ISSN:
0040-4020
Subject:
amides, carbenes, chemical reactions, chemical structure, heterocyclic nitrogen compounds, nitriles, silver
Abstract:
A first example of silver(I) N-heterocyclic carbene (Ag(I)-NHC) catalyzed on-water synthesis of primary amides by hydration of nitriles under mild reaction conditions is described. This organometallic catalytic system has excellent tolerance for various homo-aromatic, hetero-aromatic and aliphatic nitriles to afford primary amides in good yields in neat water.
Agid:
6335350