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Cationic Pd(II) catalyzed regioselective intramolecular hydroarylation for the efficient synthesis of 4-aryl-2-quinolones

Author:
Singh, Karandeep, Malviya, Bhanwar Kumar, Verma, Ved Prakash, Badsara, Satpal Singh, Bhardwaj, Vimal K., Sharma, Siddharth
Source:
Tetrahedron 2019 v.75 no.17 pp. 2506-2520
ISSN:
0040-4020
Subject:
Suzuki reaction, catalytic activity, chemical structure, iodine, organic compounds, palladium, regioselectivity
Abstract:
A divergent regioselective palladium (II) catalyzed approach through post Ugi cyclization is described. The Ugi adduct underwent intramolecular ortho-hydroarylation via 6-endo-dig cyclization for the direct access to 4-aryl-2-quinolones. Incorporation of iodine at the C-3 position of 2-quinolone followed by Suzuki-Miyaura coupling results into the more diversified 3,4-diaryl-2-quinolones.
Agid:
6335358