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Human Immunology through the Lens of Evolutionary Genetics

Author:
Quintana-Murci, Lluis
Source:
Cell 2019 v.177 no.1 pp. 184-199
ISSN:
0092-8674
Subject:
defense mechanisms, evolution, genes, genetic variation, human population, humans, immune response, pathogens, population genetics
Abstract:
Pathogen-imposed selection pressures have been paramount during human evolution. Detecting such selection signatures in ancient and modern human genomes can thus help us to identify genes of temporal and spatial immunological relevance. Admixture with ancient hominins and between human populations has been a source of genetic diversity open to selection by infections. Furthermore, cultural transitions, such as the advent of agriculture, have exposed humans to new microbial threats, with impacts on host defense mechanisms. The integration of population genetics and systems immunology holds great promise for the increased understanding of the factors driving immune response variation between individuals and populations.
Agid:
6335820