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Fabrication of BSA-Pinus koraiensis polyphenol-chitosan nanoparticles and their release characteristics under in vitro simulated gastrointestinal digestion
- Wang, Lu, Li, Xiaoyu, Wang, Hongchao
- Food & function 2019 v.10 no.3 pp. 1295-1301
- Pinus koraiensis, ambient temperature, chitosan, digestive juices, functional foods, gastrointestinal system, in vitro digestion, models, nanoparticles, particle size, physicochemical properties, polyphenols, seed cones, storage quality, zeta potential
- BSA and chitosan were used to prepare nanoparticles of polyphenols from the pine cones of Pinus koraiensis (PKP-NPs). The physicochemical properties including the average particle size, zeta potential, crystal characteristics and morphology of PKP-NPs were measured. PKP-NPs were semi-crystalline, and possessed spherical and almost uniformly sized morphological features. The rheological particle size of PKP-NPs was 187.9 ± 16.32 nm, and the zeta potential was −7.34 ± 0.24 mV. In addition, PKP-NPs showed excellent storage stability at room temperature. Through establishment of a simulated gastrointestinal digestion model, the release behavior and phenolic composition of PKP-NPs were respectively investigated. The results showed that nano-encapsulation could significantly elevate the sustained-release characteristics of PKP. After simulated digestion, the phenolic composition in digestive juice was totally different from that of non-encapsulated PKP, but partially consistent with that of non-digested PKP. The present research provided a theoretical basis for PKP-NPs as a novel nutrient to be used in the functional food field.