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Co-polysomy of 1p/19q in glial tumors: Retrospective analysis of 221 cases from single center

Author:
Kuskucu, Aysegul, Tuysuz, Emre Can, Gurkan, Sezin, Demir, Zeynel, Yaltirik, Cumhur Kaan, Ozkan, Ferda, Ekici, Isin Dogan, Bayrak, Omer Faruk, Ture, Ugur
Source:
Gene 2019 v.701 pp. 161-168
ISSN:
0378-1119
Subject:
bioinformatics, brain neoplasms, fluorescence in situ hybridization, frontal lobe, genome, glioma, neuroglia, patients, prognosis, retrospective studies
Abstract:
Glial tumors are malignant brain tumors that arise from glial cells of brain or spine and have genetic aberrations in their genome. 1p/19q co-deletion is associated with increased Overall Survival (OS) time with enhanced response to chemo- and radio-therapy in oligodendrogliomas. However, prognostic significance of 1p/19q co-polysomy is still unclear. We evaluated 1p/19q status of 221 patients with glial tumor by Fluorescent in situ Hybridization (FISH). Records of the patients were collected retrospectively. Our results demonstrated that 1p/19q co-polysomy was associated with decreased OS time, high P53 expression and frequently located in temporal lobe, whereas 1p/19q co-deletion was associated with increased overall survival time, low P53 expression and frontal lobe location. Furthermore, classification of patients based on both 1p/19q status and P53 expression revealed that patients with 1p/19q co-polysomy and high P53 expression had the worst prognosis. Lastly, our bioinformatic survival analysis revealed that high expression of SRM, ICMT, and FTL located in 1p36.13-p36.31 and 19q13.2-q13.33 region were related with decreased OS time in patients with Low Grade Glioma (LGG). The study demonstrated that 1p/19q co-polysomy is a poor prognostic marker for glial tumor.
Agid:
6339128