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Long non-coding RNA 520 is a negative prognostic biomarker and exhibits pro-oncogenic function in nasopharyngeal carcinoma carcinogenesis through regulation of miR-26b-3p/USP39 axis

Author:
Xie, Tao, Pi, Guoliang, Yang, Bin, Ren, Hui, Yu, Jing, Ren, Qingrong, Zhou, Xiaoyi, Hu, Desheng, Zhang, Haiyuan, Zhang, Hao, Zhang, Qu, Hu, Liu, Li, Ying, Zhou, Fuxing
Source:
Gene 2019 v.707 pp. 44-52
ISSN:
0378-1119
Subject:
biomarkers, carcinogenesis, carcinoma, cell growth, non-coding RNA, patients, prognosis, proteinases, signal transduction
Abstract:
Long non-coding RNAs (lncRNAs) have been wildly verified to modulate multiple tumorigenesis, especially nasopharyngeal carcinoma (NPC). In present study, we aims to investigate the role and mechanism of LINC00520 in the NPC carcinogenesis. Results indicated that LINC00520 was significantly increasing in NPC tissues and cells in comparison to their corresponding controls. Moreover, the aberrant overexpression of LINC00520 indicated the poor prognosis of NPC patients. Silence of LINC00520 was able to repress NPC cell growth in vitro while overexpression of LINC00520 inversed this process. Moreover, in vivo tumor xenografts were establishing using CNE-1/SUNE-1 cells to investigate the function of LINC00520 in NPC tumorigenesis. Rescue assay was conducting to further confirm that LINC00520 contributed to NPC progression by regulating miR-26b-3p/ubiquitin-specific protease 39 (USP39) signal pathway. Taken together, our study discovered the oncogenic role of LINC00520 in clinical specimens and cellular experiments, showing the potential LINC00520/miR-26b-3p/USP39 pathway. This results and findings provide a novel insight for NPC tumorigenesis.
Agid:
6339159