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Biotransformation of organic acids to their corresponding alcohols by Thermoanaerobacter pseudoethanolicus
- Scully, Sean M., Brown, Aaron, Ross, Andrew B., Orlygsson, Johann
- Anaerobe 2019 v.57 pp. 28-31
- Thermoanaerobacter, acetates, biotransformation, butanol, carbon, feedstocks, glucose, metabolism, stable isotopes
- Higher order alcohols, such as 1-butanol and 1-hexanol, have a large number of applications but are currently prepared from non-renewable feedstocks. Here, the ability of Thermoanaerobacter pseudoethanolicus to reduce short-chain fatty acids to their corresponding alcohols using reducing potential generated by glucose catabolism with yields between 21.0 and 61.0%. 13C-labelled acetate, 1-propionate and 1-butyrate demonstrates that exogenously added fatty acids are indeed reduced to their corresponding alcohols. This mode of producing primary alcohols from fatty acids using a thermophilic anaerobe opens the door for the production of such alcohols from low-value materials using an inexpensive source of reducing potential.