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Sequencer Hacking Unlocks Quantitative Protein Studies
- Barber, Karl W., Elledge, Stephen J.
- Molecular cell 2019 v.73 no.5 pp. 863-865
- DNA, amino acids, enzyme activity, protein-protein interactions
- In this issue of Molecular Cell, Layton et al. (2019) repurpose a common next-generation DNA sequencer to enable high-throughput protein biochemical studies, identifying improved sequence variants for stronger protein-protein interactions and dissecting the contributions of specific amino acids to enzymatic activity.