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TARGET-seq Takes Aim at Cancer Evolution through Multi-omics Single-Cell Genotyping and Transcriptomics
- Chaligne, Ronan, Nam, Anna S., Landau, Dan A.
- Molecular cell 2019 v.73 no.6 pp. 1092-1094
- genotype, genotyping, neoplasm cells, neoplasms, phenotype, somatic mutation, transcription (genetics), transcriptome, transcriptomics
- In this issue of Molecular Cell, Rodriguez-Meira et al. (2019) present TARGET-seq, an elegant single-cell method that genotypes somatic mutations and captures whole transcriptomes in the same tumor cells, thus paving the way to directly link somatic mutations with resulting transcriptional phenotypes in clonally diverse cancer populations.