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TARGET-seq Takes Aim at Cancer Evolution through Multi-omics Single-Cell Genotyping and Transcriptomics

Author:
Chaligne, Ronan, Nam, Anna S., Landau, Dan A.
Source:
Molecular cell 2019 v.73 no.6 pp. 1092-1094
ISSN:
1097-2765
Subject:
genotype, genotyping, neoplasm cells, neoplasms, phenotype, somatic mutation, transcription (genetics), transcriptome, transcriptomics
Abstract:
In this issue of Molecular Cell, Rodriguez-Meira et al. (2019) present TARGET-seq, an elegant single-cell method that genotypes somatic mutations and captures whole transcriptomes in the same tumor cells, thus paving the way to directly link somatic mutations with resulting transcriptional phenotypes in clonally diverse cancer populations.
Agid:
6341878