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Anti-obesity effects of chondroitin sulfate oligosaccharides from the skate Raja pulchra

Li, Wen, Kobayashi, Taishi, Moroi, Syoichi, Kotake, Hiroki, Ikoma, Tomokazu, Saeki, Hiroki, Ura, Kazuhiro, Takagi, Yasuaki
Carbohydrate polymers 2019 v.214 pp. 303-310
Raja, adipocytes, adipose tissue, animal models, blood serum, cartilage, cattle, chondroitin sulfate, endotoxins, enzyme activity, enzyme inhibition, food intake, high fat diet, intestinal absorption, liver, molecular weight, obesity, oligosaccharides, sharks, tissue weight, triacylglycerol lipase, triacylglycerols
We aimed to investigate the anti-obesity effects of chondroitin sulfate (CS) oligosaccharides obtained from cartilage of the skate Raja pulchra and to compare them with those of CSs of other molecular weights (MWts) (skate CS polysaccharides) and origins (shark CS, bovine CS). CSs suppressed pancreatic lipase activity as well as proliferation and lipid accumulation in mature adipocytes. Higher MWt CS had a greater lipase inhibitory activity than lower MWt CS. CSs of different origin show differing potencies for lipase inhibition and effects on adipocytes. Also, dietary intake of skate CS oligosaccharides could ameliorate obesity in high-fat diet mice model: it prevented gaining in body weight, liver weight and adipose tissue weight, maintained lower food consumption, inhibited intestinal absorption of triglyceride, and adjusted the serum endotoxin level. In conclusion, skate CS oligosaccharides have an anti-obesity activity, and the MWt and origin of the CSs may affect this activity.