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Sodium carboxymethyl cellulose modulates the stability of cinnamaldehyde-loaded liposomes at high ionic strength

Wang, Xuejiao, Liu, Li, Xia, Shuqin, Muhoza, Bertrand, Cai, Jibao, Zhang, Xiaoming, Duhoranimana, Emmanuel, Su, Jiakun
Food hydrocolloids 2019 v.93 pp. 10-18
bioactive compounds, carboxymethylcellulose, encapsulation, hydrocolloids, ionic strength, microstructure, molecular weight, particle size, rheology, transmission electron microscopes, transmission electron microscopy, viscoelasticity
In present study, three kinds of sodium carboxymethyl cellulose (CMCNa) were used to modulate the stability of cinnamaldehyde-loaded liposomes at high ionic strength (0.66 mol/L). The effects of different types and concentrations of CMCNa on the physical properties of liposomes were characterized by rheological properties, appearance, distribution, microstructure, particle size and dispersion. Rheology measurements showed that CMCNa endowed viscoelasticity to liposomes. The molecular mass (Mw) and concentration of CMCNa were positively correlated to liposome stability. CMCNa with Mw 1,185,955 was the most effective for liposomes stability at concentrations of 0.8% and 1.0% (w/v). Transmission electron microscope (TEM) results showed that CMCNa-П formed an associated layer around liposomes. Steric hindrance between particles was attributed to the improvement of stability of liposomes. Dispersion analysis demonstrated 0.8% and 1.0% CMCNa-П had the better stability. These results may contribute to the development of stable liposomes with potential applications for bioactive molecules encapsulation and delivery.