Jump to Main Content
Gap 2 phase: making the fundamental decision to divide or not
- Umeda, Masaaki, Aki, Shiori S, Takahashi, Naoki
- Current opinion in plant biology 2019 v.51 pp. 1-6
- DNA, cell cycle checkpoints, cell proliferation, cyclin-dependent kinase, genome, mitosis, transcription factors
- The Gap phases of the cell cycle are essential to perceive internal and external signals and control cell division and differentiation. However, our knowledge of molecular mechanisms underlying G2 progression in plants remains quite limited. In this review, we summarize recent findings about core G2-phase regulators, such as B-type cyclin-dependent kinases (CDKs) and R1R2R3-type MYB transcription factors. We highlight developmental and stress signals that regulate expression and accumulation of the G2-phase regulators, and discuss how they fine-tune mitotic CDK activity and control cell proliferation, endoreplication and cell cycle checkpoints. A particular focus is on DNA damage-induced G2 arrest, which is prerequisite for maintenance of genome stability.