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Aster koraiensis extract lowers postprandial glucose in normoglycemic and high-fat-diet-induced obese mice

Kim, Junghyun, Hyun, Soo-Wang, Lee, Ik Soo, Jo, Kyuhyung, Kim, Young Sook, Kim, Jin Sook, Kim, Chan-Sik
Food science and biotechnology 2019 v.28 no.2 pp. 563-568
adipocytes, animal disease models, blood, blood glucose, gene expression, glucose, glucose tolerance tests, glucose transporters, glycemic effect, herbal medicines, high fat diet, insulin, mice, muscles, noninsulin-dependent diabetes mellitus, obesity, oral administration
The Aster koraiensis extract (ASKO) is a newly developed dietary herbal supplement. In this study, the potent blood glucose-lowering activity of ASKO in vitro and in vivo was investigated. In an in vitro glucose uptake assay, ASKO was found to enhance glucose transport in 3T3-L1 adipocytes. Oral administration of ASKO significantly reduced glucose levels in normoglycemic mice during oral glucose tolerance tests (OGTTs). In a long-term efficacy study, 4 weeks of oral ASKO treatment significantly attenuated blood glucose levels during OGTTs in diet-induced obese (DIO) mice. ASKO also enhanced plasma insulin levels after glucose loading, leading to a reduction in blood glucose levels. In addition, ASKO normalized glucose transporter-4 mRNA expression in the muscles of DIO mice. These results indicate that ASKO has postprandial glucose-lowering effects and could be beneficial in the management of prediabetes or type 2 diabetes mellitus.