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Chitosan nanopolymers: An overview of drug delivery against cancer

Shanmuganathan, Rajasree, Edison, Thomas Nesakumar Jebakumar Immanuel, LewisOscar, Felix, Kumar, Ponnuchamy, Shanmugam, Sabarathinam, Pugazhendhi, Arivalagan
International journal of biological macromolecules 2019 v.130 pp. 727-736
adverse effects, biocompatibility, biodegradability, chitosan, cost effectiveness, death, drug delivery systems, drugs, genes, mechanism of action, nanotechnology, neoplasm cells, neoplasms, proteins
Cancer is becoming a major reason for death troll worldwide due to the difficulty in finding an efficient, cost effective and target specific method of treatment or diagnosis. The variety of cancer therapy used in the present scenario have painful side effects, low effectiveness and high cost, which are some major drawbacks of the available therapies. Apart from the conventional cancer therapy, nanotechnology has grown extremely towards treating cancer. Nanotechnology is a promising area of science focusing on developing target specific drug delivery system for carrying small or large active molecules to diagnose and treat cancer cells. In the field of nanoscience, Chitosan nanopolymers (ChNPs) are been emerging as a potential carrier due to their biodegradability and biocompatibility. The easy modification and versatility in administration route of ChNPs has attracted attention of researchers towards loading chemicals, proteins and gene drugs for target specific therapy of cancer cells. Therefore, the present review deals with the growing concern towards cancer therapy, introduction of ChNPs, mode of action and other strategies employed by researchers till date towards cancer treatment and diagnosis ChNPs.