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Chondroitin sulfate-functionalized polymeric nanoparticles for colon cancer-targeted chemotherapy

Zu, Menghang, Ma, Lijun, Zhang, Xueqing, Xie, Dengchao, Kang, Yuejun, Xiao, Bo
Colloids and surfaces 2019 v.177 pp. 399-406
apoptosis, chondroitin sulfate, colon, colorectal neoplasms, drug delivery systems, drug therapy, drugs, hydrodynamics, in vitro studies, mice, nanoparticles, neoplasm cells, particle size distribution, polymers, toxicity
Targeted delivery of chemotherapeutic drugs to tumors is a major challenge in colon cancer chemotherapy. To overcome this bottleneck, we loaded camptothecin (CPT) into polymeric nanoparticles (NPs), and further functionalized their surface with chondroitin sulfate (CS). The resulting CS-CPT-NPs had a desirable hydrodynamic diameter (289 nm), narrow particle size distribution (polydispersity index = 0.192) and neutral surface charge. Furthermore, in vitro experiments revealed that the surface functionalization of CS endowed NPs with the capacity of colon cancer-targeted drug delivery, and significantly improved the anti-colon cancer activities and pro-apoptosis effects against colon cancer cells. Strikingly, treatment of colon tumor-bearing mice with different NPs clearly indicated that CS-CPT-NPs showed much better therapeutic outcomes than non-targeted NPs and no systemic toxicity. Taken together, these results demonstrated the promising potential of CS-CPT-NP as an effective drug delivery system for colon cancer-targeted chemotherapy.