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Apoptosis induced by luteolin in breast cancer: Mechanistic and therapeutic perspectives

Ahmed, Salman, Khan, Haroon, Fratantonio, Deborah, Hasan, Muhammad Mohtasheemul, Sharifi, Simin, Fathi, Nazanin, Ullah, Hammad, Rastrelli, Luca
Phytomedicine 2019 v.59 pp. 152883
anticarcinogenic activity, apoptosis, breast neoplasms, breasts, chemoprevention, curcumin, cyclophosphamide, doxorubicin, drug therapy, genistein, luteolin, nonsteroidal anti-inflammatory agents, phytopharmaceuticals, polyphenols, quercetin, resveratrol, surveys, synergism, women
Breast cancer is worldwide commonly found malignancy in women and effective treatment is regarded as a huge clinical challenge even in the presence of several options. Extensive literature is available that demonstrating polyphenols, the richly introduce phytopharmaceuticals as anticancer agents. Among these polyphenols, resveratrol, silibinin, quercetin, genistein, curcumin reported to have an awesome potential against breast cancer. However, till now no comprehensive survey found about the anticarcinogenic properties of luteolin against breast cancer.This review targeted the available literature on luteolin in the treatment of breast cancer, effects in combination with other anticancer drugs with possible mechanisms.An outstanding therapeutic potential of luteolin in the treatment of breast cancer has been recorded not just as a chemopreventive and chemotherapeutic agent yet complemented by its synergistic effects with other anticancer therapies such as cyclophosphamide, doxorubicin, and NSAID such as celecoxib, and possible underlying mechanisms. Ideally, this review will open new dimensions for luteolin as an effective and safe therapeutic agent in diminishing breast cancer.