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Dynamical systems approaches to personalized medicine

Author:
Davis, Jacob D, Kumbale, Carla M, Zhang, Qiang, Voit, Eberhard O
Source:
Current opinion in biotechnology 2019 v.58 pp. 168-174
ISSN:
0958-1669
Subject:
biomarkers, computational methodology, humans, precision medicine, risk factors
Abstract:
The complexity of the human body is a major roadblock to diagnosis and treatment of disease. Individuals may be diagnosed with the same disease but exhibit different biomarker profiles or physiological changes and, importantly, they may respond differently to the same risk factors and the same treatment. There is no doubt that computational methods of data analysis and interpretation must be developed for medicine to evolve from the traditional population-based approaches to personalized treatment strategies. We discuss how computational systems biology is contributing to this current evolution.
Agid:
6346853