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SnapShot: Cancer Immunotherapy with Oncolytic Viruses
- Gujar, Shashi, Bell, John, Diallo, Jean-Simon
- Cell 2019 v.176 no.5 pp. 1240
- gene therapy, immune response, immunotherapy, metastasis, neoplasm cells, neoplasms, viruses
- Oncolytic viruses (OVs) preferentially infect and kill cancer cells without harming normal cells. OVs can revert cancer-associated immune suppression and initiate clinically meaningful antitumor immune responses. OVs and their resultant immunological events can act at both primary and metastatic sites. Thus, OVs can be exploited for cancer gene therapies and immunotherapies alone or in combination with other interventions, including immune checkpoint blockade.