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Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

Author:
Fraioli, R., Neubauer, S., Rechenmacher, F., Bosch, B. M., Dashnyam, K., Kim, J.-H., Perez, R. A., Kim, H.-W., Gil, F. J., Ginebra, M. P., Manero, J. M., Kessler, H., Mas-Moruno, C.
Source:
Biomaterials science 2019 v.7 no.4 pp. 1281-1285
ISSN:
2047-4849
Subject:
biocompatible materials, coatings, integrins, ligands, mesenchymal stromal cells, orthopedics, rats, stem cells, titanium
Abstract:
In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.
Agid:
6349911