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Prenatal exposure to per- and polyfluoroalkyl substances, placental steroidogenic enzyme, and cord blood reproductive hormone: A Chinese birth cohort study

Author:
Yao, Qian, Shi, Rong, Wang, Caifeng, Han, Wenchao, Gao, Yu, Zhang, Yan, Zhou, Yijun, Ding, Guodong, Tian, Ying
Source:
Environment international 2019
ISSN:
0160-4120
Subject:
animal tissues, blood serum, cohort studies, enzymes, females, hormones, males, maternal exposure, perfluorohexane sulfonic acid, perfluorooctane sulfonic acid, perfluorooctanoic acid, placenta, regression analysis, China
Abstract:
Per- and polyfluoroalkyl substances (PFASs) are widely used in China, but little is known about the association between prenatal PFASs exposure and fetal reproductive development as well as its potential mechanism.We investigated the effects of prenatal PFASs exposure on fetal reproductive hormones and its potential mechanism in relation to steroidogenic enzymes.Ten selected PFASs (n = 351) including PFOS, PFOA, PFBS, PFDA, PFDoA, PFHpA, PFHxS, PFNA, PFOSA, and PFUA, and two reproductive hormones E2 (n = 351) and T (n = 349) were measured in 351 cord blood serum samples from a Chinese birth cohort between 2010 and 2013. Three steroidogenic enzymes including P450arom (n = 125), 3β-HSD1 (n = 123), and 17β-HSD1 (n = 116) were measured in 125 placental tissue samples. Linear regression tested the associations between prenatal PFASs exposure and reproductive hormones in cord blood. Mediation analysis assessed the role of placental steroidogenic enzymes between prenatal PFASs exposure and reproductive hormones.The links between PFOA, PFHxS and E2 levels, between PFOS, PFUA, PFNA and T levels were significant. PFUA, PFNA, PFDA, PFHxS, and ∑PFASs were associated with higher P450arom levels. PFHxS was also associated with increased 3β-HSD1 and 17β-HSD1 levels. These associations were more pronounced in females than males when stratified by gender. Furthermore, 17β-HSD1 demonstrated mediating effects in the positive association between prenatal PFHxS exposure and E2 levels in females.Our findings suggested the potential impacts of prenatal PFASs exposure on fetal reproductive hormones, in which steroidogenic enzymes may play important roles. These associations were more pronounced in females than males.
Agid:
6350953