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The emerging role of ion mobility-mass spectrometry in lipidomics to facilitate lipid separation and identification

Author:
Tu, Jia, Zhou, Zhiwei, Li, Tongzhou, Zhu, Zheng-Jiang
Source:
Trends in analytical chemistry 2019 v.116 pp. 332-339
ISSN:
0165-9936
Subject:
isomers, lipids, spectroscopy, technology
Abstract:
Lipids represent an important class of biomolecules, and play numerous roles in physiological and pathological processes and activates. The enormous chemical and compositional diversity of lipids presents a significant challenge for lipidomics. The emerging technology of ion mobility-mass spectrometry (IM-MS) has provided an orthogonal separation to effectively improve resolving power and selectivity in lipid analysis. Meanwhile, IM-MS has also provided a valuable physiochemical property, namely, collision cross section (CCS), to facilitate lipid identification. In this review, we introduced the use of IM-MS technology to separate different lipid species and isomers. Then, we highlighted the applications of IM-MS for lipid structural identification in lipidomics. Finally, we discussed the potentials of IM-MS for the measurement and annotation of novel lipid species in biological samples.
Agid:
6350983