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Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir

Author:
Pedro, Kyle D., Henderson, Andrew J., Agosto, Luis M.
Source:
Virus research 2019 v.265 pp. 115-121
ISSN:
0168-1702
Subject:
HIV infections, Human immunodeficiency virus 1, carrier state, pathogenesis, virus transmission
Abstract:
HIV-1 spreads through both the release of cell-free particles and by cell-to-cell transmission. Mounting evidence indicates that cell-to-cell transmission is more efficient than cell-free transmission of particles and likely influences the pathogenesis of HIV-1 infection. This mode of viral transmission also influences the generation and maintenance of the latent reservoir, which represents the main obstacle for curing the infection. In this review we will discuss general cell contact-dependent mechanisms that HIV-1 utilizes for its spread and the evidence pointing to cell-to-cell transmission as a mechanism for the establishment and maintenance of latent infection.
Agid:
6351035