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“Oat bran reduces high-density lipoprotein cholesterol and does not potentiate metabolic syndrome remission by a low-calorie diet: A pragmatic, randomized, controlled, and open-label nutritional trial”

Author:
de Souza Leão, Leila Sicupira Carneiro, de Aquino, Luana Azevedo, Dias, Juliana Furtado, Koifman, Rosalina Jorge
Source:
Nutrition 2019
ISSN:
0899-9007
Subject:
blood glucose, body mass index, body weight, diastolic blood pressure, high density lipoprotein cholesterol, low calorie diet, metabolic syndrome, oat bran, patients, remission, soluble fiber, statistical analysis, triacylglycerols, waist circumference, weight loss
Abstract:
It is unclear whether addition of soluble fiber to a low-calorie diet potentializes weight loss and amelioration of metabolic syndrome (MetS). We analyzed the effects of oat bran on prevalence of MetS and associated disorders.A pragmatic, randomized, controlled, six-week nutritional trial was carried out in 154 outpatients (mean age 47.6 ± 12.6 years). The intervention group (n=83) received a low-calorie diet plus 40 g of oat bran per day; the control group (n=71) received a low-calorie diet only. MetS parameters and prevalence were calculated and compared (using two-tailed statistical tests) before and after follow-up.After follow-up, a significant but similar reduction was observed in MetS prevalence (40% reduction, 63.0% and 64.8% prevalence in intervention and control groups, respectively; p=0.226), body mass index, body weight, waist circumference, systolic and diastolic blood pressures, triglycerides, and blood glucose levels in both groups (p<0.05). Mean high-density lipoprotein-cholesterol was reduced in the intervention group (43.6 ± 9.6 to 41.2 ± 9.5 mg/dL; p=0.025), but not in the control group (44.6 ± 10.5 to 44.5 ± 12.1 mg/dL; p=0.890). There was no significant difference in any of the variables between the groups, although the p-value for high density lipoprotein cholesterol was almost significant (p=0.078). Calorie and dietetic fiber intake during the six-week period were similar in both groups.Daily consumption of oat bran did not potentialize the beneficial effects of a traditional low-calorie diet on the prevalence of MetS and associated disorders, and additionally reduced high-density lipoprotein cholesterol.
Agid:
6351821