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Co -Treatment of Cinnamon Extract with High-intensity Endurance Training Alleviates Metabolic Syndrome via Noncanonical WNT Signaling

Fayaz, Elham, Damirchi, Arsalan, Zebardast, Nozhat, Babaei, Parvin
Nutrition 2019
adipokines, blood glucose, blood serum, cinnamon, diabetes, exercise, females, glucose, herbal medicines, insulin, insulin resistance, laboratory animals, lipid composition, low density lipoprotein, menopause, metabolic syndrome, ovariectomy, rats, tumor necrosis factor-alpha, waist circumference, women
: The incidence of metabolic syndrome (MetS) in menopausal women is one of the main concerns of health cares. Metabolic syndrome clusters have been known to be related to imbalance in pro and anti-inflammatory adipokines such as SFRP5 and WNT5A. WNT5A induces inflammatory state to induce insulin resistance and further pathological consequences. Recent strategies to prevent progressions of MetS toward diabetes have focused on conservative treatments such as exercise and herbal medicine. Therefore, this study was aimed to investigate the mechanistic effects of co treatment of cinnamon extract and 12-week high intensity endurance training on MetS components considering the non-canonical WNT5A signaling.: Thirty-two female ovariectomized Wistar rats were divided into 4 groups of: exercise (Ova+Exe), cinnamon extract (Ova+Cin), exercise with cinnamon extract (Ova+Exe+Cin) and saline (Ova+Sal), (n = 8/group). One group of surgery without removing ovaries was considered as sham. After 3 months of experimental intervention, waist circumference, serum concentrations of glucose, insulin, lipid profile, TNF-α, WNT5A and SFRP5 were measured.: Data showed a significant reduction in serum glucose, LDL, HOMA-IR, and TNF-α, but an increase in SFRP5 level in Ova+Exe, Ova+Cin and Ova +Exe+Cin groups compared to Ova+Sal group (P < 0.05). Serum WNT5A significantly was reduced only in Ova+Exe+Cin group (P=0.02).: The present study indicates that, high-endurance training combined with aqueous cinnamon extract supplementation for 12 weeks, more efficiently alleviate insulin resistance, and metabolic dysfunctions via reduction in noncanonical WNT signaling in ovariectomized rats.