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Magnograndins J-M, elemane sesquiterpenoids from the leaves of Magnolia grandiflora and their inhibitory effects on nitric oxide production
- Ding, Lin-Fen, Liu, Jiang-Xin, Xie, Zhang-Qiao, Wang, De-Shen, Nie, Wei, Song, Liu-Dong, Wu, Xing-De, Zhao, Qin-Shi
- Phytochemistry letters 2019 v.31 pp. 121-124
- Magnolia grandiflora, acetone, inhibitory concentration 50, leaves, lipopolysaccharides, mass spectrometry, nitric oxide, nuclear magnetic resonance spectroscopy, sesquiterpenoids
- Four new elemane sesquiterpenoids, magnograndins J-M (1-4), and one known sesquiterpenoid, 12,13-diacetoxyelema-1,3-dien-6α,11-diol (5), were obtained from 70% acetone extract of the leaves of Magnolia grandiflora. Their structures were determined with extensive spectroscopic (HRMS, IR, 1D and 2D NMR) analyses. Compound 1 represented the first example of elemane sesquiterpenoid with an orthoacetate unit. Compound 4 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 value of 17.83 μM.