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Two new antiplasmodial flavonolignans from the leaves of Cecropia obtusifolia

Author:
Rivera-Mondragón, Andrés, Tuenter, Emmy, Bijttebier, Sebastiaan, Cos, Paul, Apers, Sandra, Caballero-George, Catherina, Foubert, Kenn, Pieters, Luc
Source:
Phytochemistry letters 2019 v.31 pp. 118-120
ISSN:
1874-3900
Subject:
Cecropia obtusifolia, Plasmodium falciparum, antimalarials, chemical constituents of plants, chromatography, cytotoxicity, inhibitory concentration 50, isomers, leaves, malaria, nuclear magnetic resonance spectroscopy
Abstract:
Cecropia species are traditionally used in several Latin American countries to treat various diseases including malaria. A phytochemical investigation on the leaves of Cecropia obtusifolia Bertol (Urticaceae) afforded two new flavonolignans, i.e. ent-mururin A (1) and ent-vaccinin A (2). They were isolated by means of chromatographic techniques and elucidated based on their spectroscopic (NMR, MS and optical rotation) data, and were described as new isomers of mururin A and vaccinin A. Antiplasmodial evaluation revealed that 1 and 2 were moderately active in vitro against the chloroquine-resistant strain Plasmodium falciparum K1 (IC50 4.68 μM and 7.34 μM, respectively) without cytotoxic effects up to a concentration of 64.0 μM.
Agid:
6352639