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Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

Author:
LeThese authors contributed equally., Dao, Wagner, Friederike, Takamiya, Masanari, Hsiao, I-Lun, Gil Alvaradejo, Gabriela, Strähle, Uwe, Weiss, Carsten, Delaittre, Guillaume
Source:
Chemical communications 2019 v.55 no.26 pp. 3741-3744
ISSN:
1364-548X
Subject:
biocompatibility, chemical compounds, nanoparticles, polymerization
Abstract:
We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core–shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.
Agid:
6353613