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Phosphine-catalyzed bishydrophosphorylation of electron-deficient alkynes

Author:
Salin, Alexey V., Il'in, Anton V., Faskhutdinov, Rustem I., Fayzullin, Robert R.
Source:
Tetrahedron 2019 v.75 no.18 pp. 2676-2686
ISSN:
0040-4020
Subject:
alkynes, chemical reactions, chemical structure, oxides, phosphine
Abstract:
Tertiary phosphines (n-Bu3P, Ph3P) efficiently catalyze the vicinal bis-addition of dialkyl phosphites and diaryl phosphine oxides to alkynoates though the tandem α-umpolung/β-Michael addition. This reaction offers a simple metal-free method for gram-scale preparation of practically useful bisphosphonates and bisphosphine oxides under mild conditions with high atom economy and selectivity.
Agid:
6357926