PubAg

Main content area

Asymmetric cyclizations via a sequential Michael addition/Conia-ene reaction by combining multifunctional quaternary phosphonium salt and silver catalysis

Author:
Fang, Guosheng, Zheng, Changwu, Cao, Dongdong, Pan, Lu, Hong, Haoran, Wang, Hongyu, Zhao, Gang
Source:
Tetrahedron 2019 v.75 no.18 pp. 2706-2716
ISSN:
0040-4020
Subject:
catalytic activity, chemical reactions, chemical structure, enantioselectivity, organic compounds, silver
Abstract:
A one-pot asymmetric Michael addition/Conia-ene reaction sequence, catalyzed by combination of a dipeptide-derived multifunctional quaternary phosphonium salt and Ag2CO3 has been developed, which provides a series of synthetically important chiral methylenecyclopentane derivatives in moderate to excellent yields (up to 97%) and enantioselectivities (up to 93%).
Agid:
6357929