PubAg

Main content area

Does Autophagy Promote Longevity? It Depends.

Author:
Savini, Marzia, Wang, Meng C.
Source:
Cell 2019 v.177 no.2 pp. 221-222
ISSN:
0092-8674
Subject:
Caenorhabditis elegans, autophagy, longevity, mammals, mitochondria, permeability
Abstract:
Zhou et al. challenge the well-known beneficial effect of autophagy in promoting longevity. Evidence presented demonstrate that autophagy induction coupled with increased mitochondrial permeability is detrimental to organismal health in both the nematode Caenorhabditis elegans and mammals.
Agid:
6358235