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The protective role of autophagy in sepsis
- Feng, Ying, Liu, Boyi, Zheng, Xiang, Chen, Li, Chen, Wei, Fang, Zhicheng
- Microbial pathogenesis 2019 v.131 pp. 106-111
- apoptosis, autophagy, defense mechanisms, immune response, inflammation, metabolism, pathogens, protective effect, sepsis (infection), therapeutics
- Sepsis is characterized by life-threatening organ dysfunction caused by a deregulated host response to infection. Autophagy is one of the innate immune defense mechanisms against microbial attack. Previous studies have demonstrated that autophagy is activated initially in sepsis, followed by a subsequent phase of impairment. A number of sepsis-related studies have shown that autophagy plays a protective role in multiple organ injuries partly by clearing pathogens, regulating inflammation and metabolism, inhibiting apoptosis and suppressing immune reactions. In this review, we present a general overview of and recent advances in the role of autophagy in sepsis and consider the therapeutic potential of autophagy activators in treating sepsis.