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Replication Licensing Aberrations, Replication Stress, and Genomic Instability

Author:
Petropoulos, Michalis, Champeris Tsaniras, Spyridon, Taraviras, Stavros, Lygerou, Zoi
Source:
Trends in biochemical sciences 2019 v.44 no.9 pp. 752-764
ISSN:
0968-0004
Subject:
DNA replication, carcinogenesis, cell cycle, evolution, genomics, oncogenes
Abstract:
Strict regulation of DNA replication is of fundamental significance for the maintenance of genome stability. Licensing of origins of DNA replication is a critical event for timely genome duplication. Errors in replication licensing control lead to genomic instability across evolution. Here, we present accumulating evidence that aberrant replication licensing is linked to oncogene-induced replication stress and poses a major threat to genome stability, promoting tumorigenesis. Oncogene activation can lead to defects in where along the genome and when during the cell cycle licensing takes place, resulting in replication stress. We also discuss the potential of replication licensing as a specific target for novel anticancer therapies.
Agid:
6359486