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How to Benchmark RNA Secondary Structure Prediction Accuracy
- Mathews, David H.
- Methods 2019
- RNA, methodology, prediction
- RNA secondary structure prediction is widely used. As new methods are developed, these are often benchmarked for accuracy against existing methods. This review discusses good practices for performing these benchmarks, including the choice of benchmarking structures, metrics to quantify accuracy, the importance of allowing flexibility for pairs in the accepted structure, and the importance of statistical testing for significance.