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Bioengineering of microbial transglutaminase for biomedical applications

Author:
Chan, Soo Khim, Lim, Theam Soon
Source:
Applied microbiology and biotechnology 2019 v.103 no.7 pp. 2973-2984
ISSN:
0175-7598
Subject:
biocompatible materials, food industry, meat, meat processing plants, peptides, protein-glutamine gamma-glutamyltransferase, structure-activity relationships, textile industry, tissue engineering
Abstract:
Microbial transglutaminase (mTGase) is commonly known in the food industry as meat glue due to its incredible ability to “glue” meat proteins together. Aside from being widely exploited in the meat processing industries, mTGase is also widely applied in other food and textile industries by catalysing the formation of isopeptide bonds between peptides or protein substrates. The advancement of technology has opened up new avenues for mTGase in the field of biomedical engineering. Efforts have been made to study the structural properties of mTGase in order to gain an in-depth understanding of the structure-function relationship. This review highlights the developments in mTGase engineering together with its role in biomedical applications including biomaterial fabrication for tissue engineering and biotherapeutics.
Agid:
6360257