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AgSCF₃-mediated trifluoromethylthiolation of α,α-diaryl allylic alcohols via radical neophyl rearrangement

Author:
Liu, Kai, Jin, Qiao, Chen, Shuang, Liu, Pei Nian
Source:
RSC advances 2017 v.7 no.3 pp. 1546-1552
ISSN:
2046-2069
Subject:
alcohols, aromatic compounds, chemical reactions, ketones
Abstract:
A novel example of AgSCF₃-mediated oxidative radical trifluoromethylthiolation of α,α-diaryl allylic alcohols is presented, producing various α-aryl-β-trifluoromethylthiolated carbonyl ketones via radical neophyl rearrangement under mild conditions. This protocol involves formation of C(Ar)–C(sp³) and C(sp³)–S bonds in one step and tolerates a wide range of symmetrical and nonsymmetrical α,α-diaryl allylic alcohols.
Agid:
6360841