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A practical iodine-catalyzed oxidative conversion of aldehydes to nitriles

Author:
Fang, Chaojie, Li, Meichao, Hu, Xinquan, Mo, Weimin, Hu, Baoxiang, Sun, Nan, Jin, Liqun, Shen, Zhenlu
Source:
RSC advances 2017 v.7 no.3 pp. 1484-1489
ISSN:
2046-2069
Subject:
aldehydes, ammonium acetate, catalysts, heterocyclic compounds, iodine, nitriles, nitrogen, oxidants
Abstract:
A simple and efficient method for the direct synthesis of nitriles from aldehydes using ammonium acetate as the nitrogen source has been developed. The reactions were performed with iodine as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant under mild conditions. A variety of aromatic, heteroaromatic, aliphatic and allylic aldehydes could be converted into their corresponding nitriles in good to excellent yields.
Agid:
6360990